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PostPosted: Fri May 29, 2015 1:44 pm 
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Phytolacca Americana (pokeweed plant)

Pokeweed antiviral protein (PAP) of the pokeweed plant, Phytolacca Americana, is a naturally occurring single-chain ribosome-inactivating protein that inhibits viral RNA synthesis. The therapeutic antiviral potential of PAP has gained considerable interest in recent years (165). Pokeweed antiviral protein from seeds (PAP-S) has the lowest toxicity and highest inhibition activity as opposed to other pokeweed antiviral proteins (166). An antimicrobial peptide against both gram positive and gram-negative bacteria has been also isolated from the seeds of pokeweed (Phytolacca americana) (167).

It has the capacity to modulate the antibody response as it has been proved by studies that the antibody response to type III pneumococcal polysaccharide (SSS-III) is enhanced by lectins from Phytolacca Americana (168). Recently, many investigators were able to isolate an antifungal peptide from seeds of Phytolacca Americana, designated PAFP-s. Its amino acid sequence corresponded to the amino acid sequence from chemical sequencing that exhibited a broad spectrum of antifungal activity (169).

Experimental studies showed that it exhibited strong antifungal activity against Candida albicans and its activity was retained even after boiling for 30 minutes and treating with proteinase K (1.0mug/mug protein) (170).
The efficacy of Phytolacca Americana used in homeopathy to treat acute tonsillitis was evaluated by clinical observation. The objective and subjective symptoms of acute tonsillitis were noted. A significant decrease in symptoms was observed as early as 2.5 days after treatment startup; no serious adverse effects were reported. It was concluded that acute tonsillitis could be treated with such a homeopathic remedy, which is characterized, by its immunomodulatory, analgesic, and anti-inflammatory properties (171).

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