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PostPosted: Thu Apr 25, 2019 12:19 pm 
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Lothar Hirneise: Onkologie 2018 – Time for Change

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Why does our heart never get cancer? Simple. And it’s got nothing to do with mutations. In order for a cell to turn into a cancer cell, the tension of the cell membrane has to decrease. What have we got in the heart? A lot of electricity! Remember what’s an ECG. And of course the electricity can’t decrease, because otherwise the heart would just stop beating. You would be dead long before a tumour could develop.

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PostPosted: Thu Apr 25, 2019 12:33 pm 
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The myocardium requires significant energy to contract continually over the human lifetime.

These energy needs are met through mitochondria, myoglobins, and rich blood supply from the coronary arteries.

The mitochondria generate ATP for the contraction of cardiomyocytes.

Myoglobins are oxygen-storing and oxygen-transferring pigments in cardiomyocytes.

Aerobic metabolism occurs when oxygen is present, while anaerobic respiration occurs when tissue is deprived of oxygen. Aerobic metabolism accounts for nearly all of the metabolic function in the heart, but anerobic metabolism may contribute as well.

Glucose reservoirs and lactate recycling allow the heart to function even during malnutrition.

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Aerobic Metabolism

Aerobic metabolism is a necessary component to support the metabolic function of the heart. Oxygen is necessary, and if even a small part of the heart is oxygen-deprived for too long, a myocardial infarction (heart attack) will occur. Coronary circulation branches from the aorta soon after it leaves the heart, and supplies the heart with the nutrients and oxygen needed to sustain aerobic metabolism. Cardiac muscle cells contain larger amounts of mitochondria than other cells in the body, enabling higher ATP production.

The heart derives energy from aerobic metabolism via many different types of nutrients. Sixty percent of the energy to power the heart is derived from fat (free fatty acids and triglycerides), 35% from carbohydrates, and 5% from amino acids and ketone bodies from proteins. These proportions vary widely with available dietary nutrients. Malnutrition will not result in the death of heart tissue in the way that oxygen deficiency will, because the body has glucose reserves that sustain the vital organs of the body and the ability to recycle and use lactate aerobically.

Heart muscle also contains large amounts of a pigment called myoglobin. Myoglobin is similar to hemoglobin in that it contains a heme group (an oxygen binding site). Myoglobin transfers oxygen from the blood to the muscle cell and stores reserve oxygen for aerobic metabolic function in the muscle cell.

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Also, many think cardiac stem cells do not exist. If this is true, the trophoblastic theory of cancer would back up why the heart seldom has cancer in that this theory relies on stem (germ) cells being the only source of cancer which are sprinkled throughout the embryo in early development, except (maybe) the heart.

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