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 Post subject: Revici work on addiction
PostPosted: Sun Jan 10, 2021 4:01 pm 
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Joined: Wed May 27, 2015 10:20 am
Posts: 497
Dr. Casriel. Right.

I met Dr. Revici, the developer of this drug, a year ago last Febru-
ary, and I guess like most of you who might have seen it for the first
time, I didn't believe my clinical eyes, but in the past 14 months I am
convinced that this is a major breakthrough, on a chemical basis, of
the addictive phenomena of addiction.

I personally have given it to about a 100 addicts, about 30 of
whom have remained in my therapeutic community, called AREBA,
which stands for the Accelerated Reeducation of Emotions, Be-
havior, and Attitude.

I have never found any hai'mful side effects from Perse per se.


RESEARCH IN DRUG ADDICTION ( By Em . Revici , M . D . ) In the past years the tremendous growth in the number of people addicted to drugs , has made of addiction à main national problem . The limited ability to cope with the first basic aspect of the problem , the medical one , has conse quently limited the efficiency of the psychological and social approaches . This explains why the problem of addiction is still practically uncontrolled . The fact that no real progress has been made in the medical control of addiction appears to result from the insufficient understanding of basic processes involved in addic tion and especially in the withdrawal syndrome . The study of the pathogenic aspect of addiction and of the withdrawal syn drome from a new angle has led us to certain conclusions concerning the nature of the processes involved . As corrolary , a new approach aimed at controlling addiction itself , without subjecting the person to the distressing withdrawal syndrome , has been developed . It has resulted in an effective short - term therapy , simple to administer , nontoxic , and inexpensive . THEORETICAL CONSIDERATION In the study of addiction and of the withdrawal syndrome we have applied our previous research concerning the mechanism involved in the pathogenesis of abnormal conditions in general , and of the intrinsic role played by lipids in these apthogeneses . In this research we have shown that symptoms , clinical and analytical signs of any abnormal condition can be integrated into one of three basic biological offbalances . Each one is characterized by its proper pathogenic metabolic processes , clinical manisfestations and analytical changes . In one of these offbalances we found that the metabolic processes have a prevalent anoxybiotic character . The metabolism of glucose , limited to the fermentative phase , leads to the appearance of acid substances , mainly lactic acid . The re sulting local acidosis is one of the main characters of this offbalance . It is the further utilization of excess hydrogen liberated in these processes that gives the occurring metabolism an anabolic character . In the second offbalance the abnormal processes concern mainly the sodium chloride metabolism . The chloride ions of sodium chloride are irreversibly fixed , while sodium ions which remain free , bind carbonic ions . This results in the appearance of alkaline substances . A local alkalosis characterizes this offbalance . The occurring dyschlorobiotic off balance has a catabolic character . In the third offbalance , the dysoxybiotic , the abnormal metabolism leads to an intensive fixation of oxygen , with the appear ance of peroxides . The study of these three offbalances has also furnished characteristic clinical and analytical data . This permits not only to define but also to recognize the offbalance present . The study of the relationship between these offbalances has shown fundamental antagonistic characters between them ; that is , between the biological processes involved , and the resulting clinical manifestations and analytical changes . Further study of these offbalances has shown the importance of the level of the organization where the abnormal processes are taking place . Clinical mani festations and analytical data were seen to differ widely if a subnuclear , cellu lar , tissue , organic or systemic level of the body organization is affected . When a condition is studied , this organizational aspect has to be considered . Moreover , these offbalances were connected with the pathogenic intervention of lipids . In the anoxybiotic offbalance , a predominance of lipids with positive polar groups , mainly sterols , was found . The dyschlorobiotic offbalance was seen to result from the intervention of a specific group of lipids with negative polar groups . These are separated as " abnormal ” fatty acids ; namely , those having trienic conjugated double bond formations in their molecules . The irreversible fixation of chloride ions , which characterizes this offbalance takes place at the conjugated double bonds of these fatty acids . In the dysoxybiotic offbalance , free unsaturated fatty acids with nonconju gated double bonds were seen to intervene . The physicochemical antagonism was seen to exist between the respective lipids which intervene in the pathogenesis of the offbalances . It could be related to the clinical and pathogenic antagonisms seen between the offbalances , as well as between the processes involved and the resulting manifestations . ; ! Ta Starting from this point . the nharmacological aspent of linids and other agents was investigated . Using each one of these three groups of lipids , it was possible to induce the respective , nffbalance . Various other agents were studied for their relationship to the lipids and their capacity to induce an offbalance . Their specific as well as their nonspecific actions could be integrated in the defined offbalances . This explains many of the pharmacodynamic properties of these agents . Based on the offbalances these agents induce they can be separated into three groups which manifest the antagonism between the offbalances . Their general character to induce an anoxybiotic , dysoxybiotic or dyschlorobiotic off balance , is associated to a specific capacity to act mainly at a certain level of the organization . The therapeutic approach was thus developed by relating these basic concepts of offbalances with the pathogenesis of the different conditions and the phar macopdynamy of different agents . In this guided therapy the nature of the agents and their doses are determined by the offbalance present in the condition to be treated . This is revealed by the clinical and analytical data obtained . In practice , analysis of a condition under this specific aspect permits to rec ognize which offbalance is present and which level is affected . Consequently , it suggests which agent has to be used in order to corret the condition . The clin ical and analytical changes induced by these agents are indicative of the neces sary changes in dosage .

ADDICTION AND WITHDRAWAL SYNDROMES It is from this specific point of view that we have approached the problem of drug addiction and withdrawal syndrome . From the interpretation of the ana lytical data and clinical manifestations it appears that the addiction itself cor responds to an anoxybiotic type of offbalance . This offbalance was seen to be induced in part directly by addicting drugs . When administered experimentally in animals , addicting drugs were seen to induce an anoxybiotic offbalance . For instance , rats with standard wound made on their back , were given drugs of the narcotic group . They induced changes toward more acid values in the pH of the crust of the wound measured on the second day . This corresponds to an anoxybiotic offbalance . A similar anoxybiotic offbalance was seen to result also from another mecha nism . When an addicting drug is introduced in the body it acts as an antigen and the body tries to defend itself against it , as it does against any antigen . However , in the specific case of the addicting drugs , the body appears unable to produce the entire progressive series of defense substances , up to the spe cifie globulins which would fully neutralize the antigen . Consequently the body ' s response remains at a lower step of this defense mechanism , with a low degree of specificity . This corresponds to release of lipids with a positive polar group . As this defense is qualitatively insufficient the body produces an excess of these defense substances . Their lipid nature with positive polar groups induces an anoxybiotic offbalance . Addiction , therefore , corresponds to an anabolic anoxy biotic offbalance which is induced directly by the addicting drug , and mainly by the excessive production of these low specific defense lipidic substances . In general the organism attempts to correct the abnormal situation created by the presence of an offbalance . This is attempted by the intervention of proc esses corresponding to an opposite offbalance . For the anoxybiotic offbalance these " correcting " processes are mainly brought about by the appearance of dyschlorobiotic processes , through the intervention of conjugated fatty acids . This dyschlorobiosis , which in the case of drug addiction occurs mainly at the systemic level of the body , is recognized through the appearance of a systemic alkalosis . We have shown that the main analytical change which corresponds to the withdrawal syndrome is the appearance of alkaline nrines , resulting from the systemie alkalosis . Manifestations such as abdominal cramps , diarrhea , vomiting , lacrimation and muscular pains appear to result mostly directly from the intensive dyschlorobiotic offbalance with systemic alkalosis . The addict may control this noxious dyschlorobiotic offbalanee , by intake of an addicting drug . By inducing anoxybiotic changes the addicting drug acts directly upon the
antagonistic dyschlorobiotic offbalance present in the withdrawal condition . When a systemic acidosis replaces the previous alkalosis , the dyschlorobiotic offbalance is temporarily controlled , Urines then change from alkaline to acid . However , as a consequence of the repeated intake of drugs , the amount of defense anoxybiotic substances , as well as the intensity of correcting dyschlorobiotic processes , is progressively increased . This results in an increasing need , an urge ,for more addicting drugs . Withdrawal of the addicting drug leaves the body of the addict under the full influence of the progressively more intensive noxious correcting processes . The dyschlorobiotic offbalance which results , with its in tensive alkalosis and the withdrawal symptoms which it induces , is thus progres sively increased
condition which explains why all withdrawal syndromes are more intensive for the first 3 to 4 days after the discontinuance of the drug , and why they decrease in intensity in the following days . This is due to the fact that although noxious , the correcting processes acting upon the anoxybiotic offbalance of the addiction itself , succeeds to reduce its intensity with time . As a corrolary , the correcting processes also decrease . THERAPEUTIC ATTEMPTS These considerations concerning the pathogenesis of addiction and of the with . drawal syndrome led us to a therapeutic approach . As mentioned above , an off balance can be induced by administration of the lipids responsible for the off balance . This is also obtained with synthetic agents which have the same basie lipoidic - physico - chemical characters . Our studies have shown that each offbalance is opposite to the two other off balances . Likewise , when one offbalance is induced it will control any one of two others . An induced dysoxybiosis may thus act against an anoxybiosis as well as upon a dyschlorobiosis . These basic considerations were used in the search for a guided therapy for drug addiction , since the addiction itself is an anoxybiosis and the withdrawal syndrome corresponds to a dyschlorobiosis . Theoretically . both should be controlled by agents able to induce a dysoxybiosis . Consequently in the therapeutic attempts we used agents which we knew from previous studies to be able of inducing a dysoxybiotic offbalance . We have found these properties in the members of the sixth series of the periodic elements ; that is , for oxygen , sulfur , selenium and tellurium . Administration of agents able to furnish oxygen in a highly reactive form temporarily influenced the withdrawal symptoms , but were unable to control addiction itself . This led us to use the second member of the series : sulfur . Inorganic bivalent sulfur compounds as well as magnesium and ammonium thiosulfates were used . We discontinued their use , for , despite effectiveness , we could not administer sufficient amounts to fully control the condition . However the clinical results obtained with these agents showed that we were on the right path . Consequently , we used bivalent negative sulfur but as organic lipidic compounds . They were mainly hydropersulfides and persulfides of unsaturated fatty acids . These compounds , although active , were however seen still not sufficiently effective to control withdrawal symptoms such as muscular cramps and vomiting . This led us to consider selenium , the third member of the series . In view of the high toxicity of most of the selenium compounds this became the main problem in therapeutic use . Previous experience with selenium preparations has shown that active selenium preparations with a very low toxicity could be obtained . These are compounds of bivalent negative selenium , with lipidic properties . We selected an organic lipidic compound of bivalent negative selenium , with the selenium bound as perselenides to unsaturated fatty acids . In experimental studies in animals this preparation induced a dysoxybiotic offhalance . It is this strong activity which seems to induce dehydrogenation which in turn changes sterols into inactive substances such as Diel ' s hydro carbon , ( the 3 methyl , 1 , 2 cyclopentanophenanthrene ) . By inactivating the ster ols they intervene in the pathogenesis of the anoxybiotic off-balance . The same processes act upon the abnormal fatty acids with conjugated double honds , leading to their inactivation . This influences the dyschlorobiotic off balance . We have been using these preparations in order to act upon the two offhalances present in drug addiction and in withdrawal symptoms . These prena rations are used as oily injectables and orally . The clinical results obtained have confirmed their therapeutical value . The important role played by the systemic alkalosis in withdrawal symptoms has led us to the use as adjuvants which have a strongly acidifying and oxidizing action . Hydrochloric acid and to a lesser extent its ammonium salt , effectively act on the syndrome . A preparation containing acidifying and oxidizing agents is used as " adjuvant . ” This preparation for control of the withdrawal syndrome is administered orally .

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