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 Post subject: Potassium ascorbate
PostPosted: Fri Oct 13, 2017 11:20 pm 
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Interesting concept:

Potassium ascorbate is a salt derived from vitamin C that is totally non-toxic and free from side effects.

The compound can be extemporaneously (i.e. without any preparation) obtained by dissolving ascorbic acid (150 mg) and potassium bicarbonate (300 mg of which 117 mg potassium) in water. It has a pH level that tends to neutralize in less than a minute. The two components have to be dissolved in 20 cc water (about two fingers high) without using a metallic spoon (because of the potential risk of oxidation of the ascorbic acid).

Potassium ascorbate is related to the studies and research of the Florentine biochemist Dr. Gianfrancesco Valsè Pantellini and its ‘story’ starts in 1948 when a goldsmith and friend of Dr. Pantellini, affected with inoperable stomach cancer, experiences unexpectedly and absolutely extraordinary results after taking lemon juice in which he accidentally dissolved potassium bicarbonate instead of sodium bicarbonate. Pantellini studied and analyzed this subject for about twenty years, leading to two specific publications in 1970 and 1974 in the Journal of Medical Pathology.

Oxidative processes linked to the presence of free radicals are involved in the impetus and development of cancer. Free radicals (substances with a high chemical reactivity) are the main reason for the mechanism of oxidative stress. Living organisms tend to maintain a constant level of the concentration of these oxidizing agents to ensure normal biological processes.

Based on the studies of Dr. Pantellini, we are convinced that oxidative stress damages cell membrane structures, in particular the sodium-potassium ATPase (also known as the Na/K pump). This causes (an initially mild) depolarization and an increasingly greater alteration of the active transport mechanism of these two electrolytes, that have very different but fundamental functions in the cellular organization; potassium is the main regulator of intracellular metabolic processes through reversible salification of amino groups and imino of enzymes and proteins in a slightly acid environment; the other, sodium, is the main regulator of the alkaline reserve of the organism at extracellular level, with reversible salification of carboxylic groups of enzymes and proteins in a more or less basic environment.

In this way we obtain an increasingly bigger modification of the acid-based environment and redox-reactions between cytoplasmic molecules.

We are convinced that this fact constitutes the activating mechanism (trigger) for mutation into a cancerogene cell. In fact, research relating to the sarcoma (malignant tumor) of Rous that was already published in the 30′s (Moraveck and Kishi) proved that the neoplastic cell is lacking potassium and rich of sodium, with an increasingly greater imbalance along with the development of cell degeneration.

This seems to be the common denominator in all neoplastic diseases and is also verifiable through a careful evaluation of the four hematic electrolytes (sodium, calcium, potassium, magnesium) in the blood.

The described mechanism turns out to be very dangerous for the cell when:

it activates a rapid transfer of calcium from intracellular deposits (mitochondria), that could be responsible for mitogenic activation (i.e. cell duplication);

it allows a considerable transport of glucose into the cytoplasm (together with sodium, SGLUT symport) with a speed that increases along with the increasingly greater alteration of the sodium/potassium pump (which is the only active control element of the two electrolytes).

These processes lead to a modification in cell respiration, with a decrease of oxidative phosphorylation and a substantial increase of glycolysis. The production of lactic acids, formed by pyruvate reduction, is also increased. Moreover, this pyruvate reduction prevents the start of the S-phase of the mitosis and its steady decrease in the cytoplasm (for the conversion into lactic acid) takes this block on mitosis away, pushing the cell towards uncontrolled proliferation.

So we have a modification of the intracellular pH that tends to become lightly alkaline, and a modification of the cellular respiration with a significant alteration of the Krebs cycle.

These facts together tend to result in an alteration in form and action of proteins and cytoplasmic enzymes, leading to a polymerization of RNA and a transfer of incorrect information between the ‘periphery’ and the ‘operative center’ (DNA). This leads to the mutation of the nuclear DNA and carcinogenesis.

In conclusion, the following hypothesis on which we are working now is that degeneration does not arise from a direct damage in the nuclear DNA, but from a problem in the cytoplasm, which means the damage occurs at the peripherical level (cell membrane). This would actually mean that operation of DNA can be strongly influenced by various components of the same cellular environment as well as by cell-to-cell signals.

From experience and data of Dr. Pantellini first and those of the Foundation now it seems that potassium ascorbate, also and especially in its newest formula with ribose, interferes with this process in a major way; it protects the cell against oxidative stress and inhibits the uncontrolled proliferation mechanism.

These facts can be related to the transporting (‘carrier’) characteristics of ascorbic acid for potassium (and with the catalytic activity of ribose in the ‘new’ formula) as a result from its heterocyclic structure, together with its antioxidant action.

The compound’s action is related to the characteristics of potassium as ‘guiding’ cation and metabolic regulator at intracellular level and to the ‘carrier’ action of vitamin C, which in this specific case performs a similar function to that of the sodium/potassium pump.

The release of potassium inside a cancerous cell can provoke a corresponding runoff of sodium (hence glucose) in the intracellular environment. In this way we can obtain:

a new modification of the local, intracellular pH;

a rapid decrease of nutritional reserves reducing glycolysis and re-establishing the potential block on mitosis. Thus, it seems possible to inhibit the uncontrolled proliferation process.

Furthermore, potassium ascorbate can effectively serve on the level of prevention, maintaining constant intracellular potassium levels. In fact, as previously explained, the imbalance of these intracellular levels with the ‘intrusion’ of sodium from extracellular areas would be responsible for (or at least highly involved in) the chain of events that could lead to transformation of a cell into a neoplastic cell. Preventive intake of potassium ascorbate therefore has the objective to protect the cell from the risk of degeneration.

In recent years, the formula has been enriched with ribose which performs a catalytic activity, increasing the speed of the process by which potassium is transferred into cells. For further information, please go to the corresponding section on this website.

Preventive intake of the compound by adults generally consists of taking one dose per day, preferably in the morning on empty stomach 15 minutes before breakfast (unless otherwise indicated based on the evaluation of blood test/parameters).

In the presence of an oncologic disease it is generally recommended to take 3 daily doses (in the morning on empty stomach, 15 minutes before breakfast; and 45 minutes before lunch and dinner).

It is always advisable to have an assessment made by a competent person in order to be able to suggest the most appropriate dose for each situation.

Dr. Guido Paoli
Scientific Director

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