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 Post subject: bleeding
PostPosted: Thu Jun 11, 2015 12:02 pm 
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Joined: Wed May 27, 2015 10:20 am
Posts: 511
Bleeding has long been a puzzle for me in my earlier racing days. I have
put fit horses out to race and conditioning seemed not to affect bleeding
occurrences. I have now come to the conclusion in all likelihood, equine
pulmonary bleeding is a symptom of a biofilm infection in the horse's lungs.
Biofilms are colonies of bacteria and possibly other microorganism types
that have found that living together, protected by a self-secreted polymeric
matrix can evade normal immune responses and foster a viable community on a
living or non living surface. Dental plaque is probably our best known and
studied biofilm, but it is becoming increasingly appreciated that biofilms
can be found anywhere in the body. Biofilms are microorganisms
characteristically encased by slimy, gluey films that help these pathogenic
microorganisms adhere to moist lung tissue and evade the horse's immune
cells and commonly administered antibiotics. Biofilms cannot easily be
cultured or detected which is probably the main reason why my theory is not
a predominant one among the veterinary community. If vets cannot culture a
biofilm, nor see any results from common administered antibiotics, they
don't think an infection is involved. A grave mistake!

A study done by Cross, Ramadan, & Thomas, The impact of Furosemide on
Pseudomonas Aeruginsoa Biofilms, found that furosemide (lasix) at 10mg/ml
reduced some biofilms by 50% at a pH of 8-9. Furosemide seemed to
destabilize biofilms at pH-dependent concentrations. Perhaps this is why
lasix, generally, but not always, seems to help race track bleeders? It is
not so much its diuretic action but rather its biofilm destabilization
characteristics that produces efficacy in the bleeding racehorse. Fusomide
seems to be only effective at proper pH and specific concentrations which in
real life could be quite variable in individual racehorses and racing
conditions and may be one reason why we see so much variation in Lasix's
efficacy on track.

A very popular herbal preparation for bleeding is YUNNAN PAIYAO. Many
horsemen swear by this Chinese herbal formulation. If you look carefully
into its properties, you will find that it contains powerful anti-infective
herbs. This clouds up the mechanism of why it seems to help bleeding
horses. Is it mostly a blood regulator, anti-hemorrhagic or is it an
antibiotic or the combination of the three? I tend to believe in the
infection induced likelihood of bleeding and suspect that the antimicrobial
action may be the key.

My webpage on EIPH can be accessed here:

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